


In basic research, solving complex problems through the collaborative efforts of researchers from a wide range of fields has become mainstream. Although the expertise of individuals is expected to be enhanced in such problem-solving scenarios, it is quite difficult for them to obtain an overall picture of the research from a bird's-eye view.
Therefore, our research institute fosters the development of young researchers via a unique approach called “conduct research independently as much as possible.” The following steps form the basis of this approach:
If you obtain unexpected results or hit a dead end in the process of advancing the research, it is also important to have the flexibility to return to the questions and replan this series of tasks. Nevertheless, difficult choices and unexpected difficulties will always arise. Accordingly, our research institute has appointed currently active, distinguished university professors as advisors that specialize in all aspects of organic chemistry, who can provide advice on solving problems. We are certain that this series of processes will enhance individual problem-solving skills and provide scholars with remarkable research driving force and adaptability, and our institute will continue to provide full support to individual young researchers.
Our institute expects young researchers to experience the entire research process at a young age, even through small-scale projects, acquire the ability to summarize research independently, and expand into broader and emerging scientific fields.
The pursuit of a sustainable society, as exemplified by the Sustainable Development Goals (SDGs), requires global-scale solutions to various challenges facing modern society, including resource depletion, rapid global population growth, climate change, and environmental issues. Addressing these challenges necessitates the development of innovative scientific and technological solutions, and organic chemistry undoubtedly stands as one of the most crucial foundational research fields. Since its establishment, the Itsuu Research Institute has been dedicated to drug discovery research rooted in organic chemistry. Today, it operates as a public interest incorporated foundation that is dedicated to advancing pharmaceutical sciences by fostering young researchers through research centered on fundamental organic chemistry. Organic chemistry plays a vital role in creating a sustainable society, and I firmly believe that nurturing the next generation of researchers who will underpin the future of this field is a mission of considerable social importance. Our goal is to enable promising young researchers to develop into world-class organic chemists and researchers who can contribute to the global community, making the most of their valuable time. To this end, it is essential that they develop into researchers who can formulate their own research topics, publish findings based on experimental validation of hypotheses, and receive peer evaluation of their work. I consider it the Itsuu Research Institute’s core mission and raison d'être to provide an environment conducive to such growth.
At the Itsuu Research Institute, young researchers embark on projects that they have independently conceived, bringing them to fruition through their own efforts. The growth of these researchers is supported by our advisory board members, each of whom has a unique research approach and provides guidance shaped by their diverse perspectives. This institute offers a valuable environment where researchers can explore new avenues of inquiry and cultivate their own scientific approaches. We hope that our researchers will leverage the experiences gained at this institute to tackle even more ambitious scientific questions and conduct original research that brings both excitement and inspiration.
I am an advisory board member serving my second term. RIKEN Institute, where I was employed prior to my current job, was once known as a "free Paradise for scientists" because of the environment where researchers could freely implement long-term projects without restriction of their ideas, based on patent income related to the method for mass producing Vitamin A developed by Prof. Dr. Umetaro Suzuki and others, and it was a Paradise that many scientists longed for. Even today, RIKEN Institute is evolving freely in all directions like an amoeba, and is leading the world in various research fields such as chemistry, physics, biology, and medicine. Truly, to achieve a "free Paradise for young researchers in the field of organic chemistry," Itsuu Laboratory is organized and operated primarily to construct a research environment in which young researchers can be dedicated to and immerse themselves in research. Researchers are free to choose their research topic, but with freedom comes great responsibility. I am consistently impressed by the presentations of young researchers who are energetically conducting daily experiments while considering the significance and ripple effects of their chosen research topic, and face the research report meeting with a sense of tension. I strongly feel that the broad smile on their faces at the social gathering after the research report meeting is proof that they are carrying out their research with a sense of responsibility. I will continue to make efforts to contribute to the process by which young researchers grow toward a larger goal while working hard and competing with each other at a high level.
The Research Foundation Itsuu Laboratory is a dynamic research organization where young organic chemists, driven by their passion and curiosity, come together to pioneer innovative scientific discovery. At the laboratory, researchers are encouraged to think freely, generatetheir own ideas, and fully engage their hands and minds in experiments, and savor the satisfaction of refining their research outcomes. The Itsuu Laboratory provides ample support in the form of advanced research facilities and funding, allowing endless possibilities for research. In addition to these resources, researchers benefit from regular consultations with a five-member advisory board, having expertise in diverse fields, to receive in-depth guidance on their progress and research direction. Above all, the Laboratory attracts passionate young researchers with varied research interests and experimental techniques, and its key appeal is that it enables the opportunity to engage in mutual growth by competing as rivals at times and collaborating as peers at others, pushing each other to improve. (As of 2024) It has been three years since I joined the advisory board of the Research Foundation Itsuu Laboratory, and I believe nowhere else is the research environment more exciting than here. I often reflect on how much I could have learned and grown if I had been part of this Laboratory in my early career. Wouldn’t you like to hone your skills in science and strive for even greater heights to contribute to groundbreaking scientific research that has the potential to change the world?
The Research Foundation Itsuu Laboratory offers an excellent environment for young researchers to improve their skills. With substantial research funding, the institution enables researchers to propose and pursue their own projects, advancing their work with confidence. I am delighted to collaborate with young ambitious individuals full of dreams. My research focuses on organic synthesis, natural product isolation, and natural product chemical biology through molecular cell biology. During my doctorate which centered on asymmetric catalyst development, I became intrigued by the biological sciences and learned experimental techniques across variety of fields under the mentorship of the faculty of several laboratories. In this way, I have had experience belonging to a variety of research labs and have been able to gain a wide range of perspectives. I anticipate young researchers to promote innovations from diverse perspectives.
As of fiscal year (FY2024), I have been appointed to the advisory board. I genuinely admire the young researchers who are in a position to freely pursue their passion in chemistry. Even on a global scale, such a supportive environment is rare and remarkable. I anticipate young researchers to promote innovations from diverse perspectives. While I still have much to learn, I hope to contribute meaningfully to the growth of these talented individuals.
After obtaining a degree, even if you join academia or get a job in industry, you will not be given an environment in which you can freely conduct the research you want for a while. In order to collaborate on and conduct a given project within the research plan, budget, and environment proposed and provided by the PI or supervisor, research will be conducted within a limited scope. If this period becomes long, before you realize, the emphasis will shift to consistently producing good results, and the spirit of challenge to create something from nothing will be lost. At Itsuu Laboratory, under the free-research environment, despite experimental techniques for organic synthesis being optimal, please constantly challenge yourself to develop new things, and realize your dream of organic chemistry as you envision it. Please present your original research results, which will be the core of your future research life, and spread your wings and soar high in the next stage. We look forward to engaging in active discussions with all of you young researchers who are passionate about organic synthetic chemistry research.
Hisashi Yamamoto, Professor and Directore, Molecular Catalyst Research Center, Chubu University
Gifu Pharmaceutical University (Assistant Professor), Juzen Chemical Corporation, Mitsubishi Chemical Corporation, Osaka University (Specially-Appointed Assistant Professor), Takasaki University of Health and Welfare (Assistant Professor), Tohoku University (Assistant Professor), Gifu University (Assistant Professor), Tohoku University (Lecturer), Hiroshima University (Assistant Professor), Meiji Pharmaceutical University (Assistant Professor), Kyoto University (Program-Specific Assistant Professor), University of Pennsylvania (Postdoctoral Researcher), Tokyo University of Science (Assistant Professor),PRISM BioLab Co., Ltd., Red Arrow Therapeutics, Inc. ,Hokkaido University(Specially-Appointed Assistant Professor), University of Nebraska-Lincoln (Assistant Professor),Kanagawa University (Assistant Professor), Institute of Science Tokyo (Specially Appointed Assistant Professor), etc.